Seeing how ketosis induced by the ketogenic diet affects these things, it is likely the ketosis induced by KETO//OS would elicit similar effects, but not perhaps exactly the same. Cortisol is a hormone produced by the adrenal glands that is tightly correlated with metabolic syndrome. Patients with metabolic syndrome have elevated blood cortisol levels which appear to be due to dysregulated cortisol metabolism. (Cortisol can be produced, cleared, or regenerated enzymatically, and abnormalities in any of these steps can cause cortisol dysfunction). In obese patients, cortisol clearance is increased and cortisol regeneration is reduced, causing an elevation in blood cortisol, which is linked to metabolic syndrome (obesity, hyperlipidemia, insulin resistance, hypertension, etc). In a study in obese men (link: http://press.endocrine.org/doi/pdf/10.1210/jc.2007-0692), Ketosis reversed the dysregulated cortisol metabolism, decreasing cortisol clearance and increasing cortisol regeneration. This too resulted in an overall increase in blood cortisol; however, importantly, it was due to the reversal of the dysregulated cortisol metabolism observed in patients with metabolic syndrome. (This is important because sometimes the increase in cortisol which occurs with Ketosis is used as a weapon for attacking the diet, but those who argue this point are majorly oversimplifying the situation and must not be aware of the intricacies of cortisol metabolism which affect metabolic health.) In this study, the changes in cortisol metabolism induced by Ketosis accompanied improvement in the symptoms of metabolic syndrome (improved weight loss, improved fasting glucose/insulin levels), suggesting that Ketosis alters cortisol metabolism and adrenal function in a way, which confers improvements in metabolic health. We are finding this to be true with the experiences KETO//OS customers are having as well.
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